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Articles
Below is a list of articles
written by Dr. Nelson Stone and Dr. Jeffrey Chircus available for download by clicking on
the article title. Each article is in Adobe Portable Document Format
(PDF) and each requires the Adobe Acrobat Reader to view. If
you don't have a copy of the Acrobat Reader, you can download a free
copy by clicking the link at the bottom of the page.
Real-Time Prostate Brachytherapy: Transition from Intraoperative
Nomogram Planning to Virtual Planning
The real-time prostate
brachytherapy technique developed by Drs. Stone and Chircus is
discussed. The method utilizes the Varian 7.1 treatment planning
system in an intra-operative approach to which allows real-time seed
and dose adjustments as the implant is created. The article presents
the technique of this method.
The
ProSeed Approach: A Mulitcenter study of the results of
Brachytherapy
Drs. Chircus and Stone
started ProSeed in 1995 as a turnkey services company which included
physician training and proctoring. This article compares the implant
outcomes, by dosimetry results, for the physicians during the
proctor phase to the post-proctor (independent) results.
Prostate Cancer in a Large Prostate Associated
with Decreased Prostate Specific Antigen Failure Rate After
Brachytherapy,
The Journal of Urology Vol. 173, pp. 79-81, January 2005
Patients with larger
prostates have a slightly better freedom from PSA relapse after
brachytherapy than smaller glands. 98% of patients with prostates
larger than 50 cc were free from failure compared to 84% for small
glands (< 30 cc) at 10 years.
Clinical
Investigation: Urinary Symptoms Flare Following I-125 Prostate
Brachytherapy,
Int. J. Radiation Oncology Biol. Phys., Vol. 56, No. 4, pp.
1085-1092, 2003
Patients may experience
an execration of their urinary symptoms 2 plus years following
brachytherapy. The actuarial likelihood of symptom flare by 5 years
is about 50%.
Clinical Investigation: Biochemical Outcomes after Prostate
Brachytherapy with 5-Year Minimal Follow-up,
Int. J. Radiation Oncology Biol. Phys., Vol. 57, No. 3, pp. 645-653,
2003
Long-term outcomes
demonstrate success of prostate brachytherapy.
Clinical Investigation: Combined Modality
Treatment in the Management of High-Risk Prostate Cancer,
Int. J. Radiation Oncology Biol. Phys., Vol. 59, No. 5, pp.
1352-1359, 2004
The best treatment for
high-risk prostate cancer is a combination of hormonal therapy,
brachytherapy and external beam irradiation. At 5 years, 86% of
high-risk patients were free of biochemical (PSA) failure and none
had local relapse.
Additional Articles:
Cancer Facts and
Figures 2007,-
American Cancer Society
12 Year Outcomes
Following Permanent Prostate Brachytherapy in Patients with
Clinically Localized Prostate Cancer,
The Journal of Urology Vol. 173, pp.
1562-1566, May 2005
Clinical Investigation: 15-Year Biochemical
Relapse-Free Survival in Clinical Stage T1-T3 Prostate Cancer
Following Combined External Beam Radiotherapy and Brachytherapy,
Int. J.
Radiation Oncology Biol. Phys.,Vol.67, No.1, pp. 57–64, 2007
Clinical
Investigation: Customized Dose Prescription for Permanent Prostate
Brachytherapy: Insights From a Multicenter Analysis of Dosimetry
Outcomes,
Int. J. Radiation
Oncology Biol. Phys.,Vol.69, No. 5, pp. 1472-1477, 2007
Clinical
Investigation: Ultra-High Dose (86.4 GY) IMRT for Localized Prostate
Cancer: Toxicity and Biochemical Outcomes,
Int. J. Radiation
Oncology Biol. Phys., pp. 1–8, 2007
Physics Contribution: Comparison of
Localization Performance with Implanted Fiducial Markers and
Cone-Beam Computed Tomography for On-Line Image-Guided Radiotherapy
of the Prostate,
Int. J.
Radiation Oncology Biol. Phys.,Vol.67, No. 3, pp. 942-953, 2007
Image-Guided
Radiotherapy for Localized Prostate Cancer: Treating a Moving
Target,
Elsevier, Dept. of
Radiation Oncology, M.D. Anderson Cancer Center, pp. 58-66
Physics Contribution:
A Study of Image-Guided Intensity-Modulated Radiotherapy with
Ficucials for Localized Prostate Cancer Including Pelvic Lymph Nodes,
Int. J. Radiation
Oncology Biol. Phys.,Vol.68, No. 6, pp. 898-902, 2007
Clinical
Investigation: Patient-Assessed Late Toxicity Rates and Principal
Component Analysis After Image-Guided Radiation Therapy for Prostate
Cancer,
Int. J. Radiation
Oncology Biol. Phys.,Vol.68, No. 3, pp. 690-698, 2007
Clinical
Investigation: Multi-Institutional Analysis of Long-Term Outcome for
Stages T1-T2 Prostate Cancer Treated with Permanent Seed
Implantation,
Int. J. Radiation
Oncology Biol. Phys.,Vol.67, No. 2, pp. 327-333, 2007
Intermediate Term
Biochemical-Free Progression and Local Control Following Iodine
Brachytherapy for Prostate Cancer,
The Journal of Urology,
Vol.173, pp. 803-807, March 2005
Long-Term Urinary, Sexual and Rectal Morbidity
in Patients Treated with Iodine-125 Prostate Brachytherapy Followed
Up for a Minimum of 5 Years,
Elsevier,
pp. 338-342, 2007
Physics Contribution: Daily Variations in
Delivered Doses in Patients Treated with Radiotherapy for Localized
Prostate Cancer,
Int. J.
Radiation Oncology Biol. Phys.,Vol.66, No. 3, pp. 876-882, 2006
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